Having undergone peritoneal dialysis for close to 3 years and going in and out of the Emergency Department of Tan Tock Seng Hospital 6 times in 2024 due to my lungs being overloaded with water, I was at the point of pure frustration as I thought I had done what I could. What am I missing, and what was wrong with me?

It was then that I decided to make some drastic changes to my lifestyle. Deciding to invest in a quality hydrogen inhalation machine and a hydrogen water machine was one of those changes that I made after researching their effectiveness in helping dialysis patients improve their quality of life.

Staying consistent with my inhalation regimen, along with drinking hydrogen-rich water, has helped me to cope with the demands of dialysis treatments better. I have since switched to hemodialysis on 30 September 2024.

I find that the clearance is much better than peritoneal dialysis in my case. Always consult your primary healthcare provider before making any changes to your lifestyle.

In this article, I will share what I have learnt from my months of research and personal experience.

Please feel free to contact me if you are interested to learn more about this therapy and where you can try it first.

• Hydrogen inhalation therapy delivers H₂ gas directly to the lungs, offering potential antioxidant and anti-inflammatory benefits.
  
  
• Top machines in 2025 feature high flow rates (up to 1500 mL/min), 99.999% purity, and medical-grade PEM tech for safe daily use.
  
  
• Scientific studies have shown promising effects for fatigue, inflammation, and neurological conditions, but further research is needed.
  
  
• Devices like the AirForest from The H2 Therapy provide a reliable, home-based option for serious wellness users.
  
  
• Always choose machines with certifications and safety features, and consult a doctor who is familiar with hydrogen therapy if you have existing health concerns.

Hydrogen inhalation therapy involves breathing in molecular hydrogen (H₂) gas through a nasal cannula or face mask using a machine that generates highly pure H₂ gas from water.

Unlike hydrogen water, which is consumed, inhalation delivers hydrogen directly to the lungs, allowing it to diffuse into the bloodstream and the tissues more rapidly.

Molecular hydrogen gas is odorless, tasteless, and non-toxic. It is being studied for its selective antioxidant properties, meaning it may neutralize only harmful free radicals, such as hydroxyl radicals, without disrupting beneficial reactive species.

The unique properties of hydrogen gas include its ability to cross the blood-brain barrier due to its small molecular size, making it particularly interesting for neurological applications. This selectivity has been shown in many preclinical studies.

Recent clinical trials have advanced our understanding of hydrogen inhalation therapy.

Keio University, a leading institution in hydrogen research, published groundbreaking results in 2023 from their HYBRID II trial — a multicenter, randomized, double-blind study that looked at hydrogen’s effects on cardiac arrest patients.

The research, conducted by the university’s medical team, marks a significant milestone in the field of hydrogen medicine.

In the HYBRID II trial, patients who received hydrogen inhalation therapy had a 56% favorable neurological outcome rate, compared to 39% in the control group. The 90-day survival rate without severe neurological deficits improved from 21% to 46%.

This is one of the biggest breakthroughs in hydrogen medicine to date.

Brain Function and Neuroprotective Effects

Brain function research has shown that molecular hydrogen crosses the blood-brain barrier rapidly, with brain tissue reaching saturation within 6.3-9.4 minutes of inhalation.

This rapid absorption rate is why hydrogen therapy may be effective for neurological conditions.

Studies suggest that hydrogen levels in the body can provide neuroprotective effects, but more research is needed to determine optimal dosing protocols.

Exercise Performance and Muscle Fatigue

A significant 2024 study published by Hebrew SeniorLife found that hydrogen-rich gas inhalation before exercise can reduce muscle fatigue.

A randomized crossover study involving 24 healthy men demonstrated that 60 minutes of hydrogen gas inhalation before cycling exercise reduced fatigue scores and improved performance metrics.

Participants had higher cycling frequency in the last 30 seconds and lower serum lactate levels indicating reduced metabolic stress.

Cardiovascular and Metabolic Health Conditions

Recent research has expanded hydrogen’s applications beyond acute care. A large-scale retrospective study with 1,088 Type 2 diabetes patients found that hydrogen inhalation therapy produced better glycemic control than conventional treatment alone, with HbA1c reductions of -0.94% vs -0.46% in controls over 6 months.

Cardiovascular research is also showing promising results. Studies indicate that hydrogen inhalation can reduce systolic blood pressure by approximately 4.8 mmHg over a 2-week period when used as adjunctive therapy. However, further research is needed to confirm its long-term effects.

Kidney Health and Dialysis Support

This 2022 review highlights the potential of hydrogen therapy in treating kidney diseases by acting as a selective antioxidant to reduce harmful oxidative stress and inflammation, while protecting beneficial reactive oxygen species.

Animal studies show that hydrogen can lessen kidney injury, slow fibrosis, and improve outcomes in various renal conditions, but further human clinical trials are needed to confirm its effectiveness and safety.

Another 2025 study explores the combination of hydrogen gas inhalation with hydrogen-enriched dialysate during hemodialysis, finding that this approach significantly reduces oxidative stress and improves patients’ quality of life and well-being scores.

While the results are promising, further research is needed to standardize the treatment and confirm its benefits for routine clinical use.

The mechanism by which hydrogen inhalation machines produce therapeutic gas involves electrolysis of water.

At the molecular level, hydrogen generation occurs when electrical current passes through water, splitting H₂O molecules into hydrogen and oxygen components.

The most effective systems use PEM (Proton Exchange Membrane) technology, which ensures high hydrogen purity levels.

Modern hydrogen gas production systems must meet certain technical requirements. Hydrogen purity should be maintained at a minimum of 99.99% for therapeutic applications.

The hydrogen output flow rate is typically 150-300 ml/min for personal use and up to 3,000 ml/min for clinical use. Flow rate is critical because it determines the hydrogen concentration that reaches the lungs and then the bloodstream.

Some systems also produce oxygen gas separately, which can be beneficial for users who need supplemental oxygen therapy.

Choosing the best hydrogen inhalation device requires understanding several technical specifications:

1. Hydrogen Output Flow Rate: Higher flow rates (600-3000 mL/min) may be more effective. However, research indicates that concentrations of 2-4% can also be effective.

2. Hydrogen Purity: The goal is 99.999% pure H₂ gas. Lower purity may introduce contaminants that reduce therapeutic benefits or pose safety risks.

3. Electrolysis Technology: SPE/PEM membrane technology is preferred for the clean generation of hydrogen over alkaline electrolysis systems. This is easy to maintain and provides consistent gas quality.

4. Water Requirements: Use only distilled water or purified water with a total dissolved solids concentration of less than 5 ppm. This ensures optimal hydrogen production and prevents damage to equipment.

5. Safety Features: Flame arrestors, overpressure shut-off systems and proper ventilation to prevent hydrogen accumulation are essential.

What I Like:

• High hydrogen concentration delivery

• Auto shut-off safety features

• Built-in humidification system

• Suitable for daily use

What I Didn't Like:

• Not the most compact design

• Higher initial investment

Verdict: A reliable and robust machine for those serious about long-term hydrogen therapy. It is particularly effective for users seeking clinical-grade hydrogen concentrations at home.

What I Like:

• Premium build quality with advanced features

• Quiet operation for extended use

• Professional grade components

What I Don't Like:

• Higher price point

Verdict: For biohackers and wellness clinics who want premium hydrogen gas inhaler technology with a professional look.

What I Like:

• Dual-port hydrogen + oxygen system for single or dual-user use

• High-purity H₂ production with built-in safety sensors

• Hydrogen water generation capability included

• Smart display with night/day modes and quiet operation

• Strong customer support and warranty coverage

What I Don't Like:

• Bulky and heavy—less ideal for portable setups

• Premium price with additional filter maintenance costs

• Limited number of verified Amazon reviews

Verdict: Ideal for dedicated hydrogen therapy users who want both inhalation and hydrogen-rich water in one powerful, clinic-grade system. Best suited for home health enthusiasts or wellness centers.

What I Like:

• Lightweight and travel-friendly design

• Easy to use interface

• Affordable entry point for hydrogen therapy

• Convenient for users who want to inhale hydrogen regularly without being confined to one location

What I Dislike:

• Lower flow rate compared to clinical units

• May require longer treatment sessions

Verdict: Best for beginners or users who need portability without compromising on hydrogen purity and safety. Among portable hydrogen inhalers, this model offers excellent value for money.

What I Like:

• Versatile system offering multiple hydrogen delivery methods

• Quality Japanese engineering

• Good value for multi-modal hydrogen therapy

What I Dislike:

• Moderate hydrogen gas flow rate

• May not satisfy users seeking high-concentration gas therapy

Verdict: Good choice for users who want both hydrogen water and gas inhalation capabilities in a single system.

One of the most important considerations when choosing a hydrogen inhaler is understanding the difference between pure molecular hydrogen and oxyhydrogen (also known as Brown’s gas or HHO) therapy approaches.

Pure Hydrogen Therapy

Pure molecular hydrogen therapy involves inhaling 99.99% hydrogen gas, with oxygen separately expelled during the electrolysis process.

This approach maximizes the concentration of hydrogen delivered to the respiratory system, ensuring the highest possible therapeutic dose.

On the clinical front, pure hydrogen therapy is a preferred method for researchers studying dose-response relationships.

Advantages of Pure Hydrogen:

• Maximum hydrogen concentration delivery

• Suitable for users with specific health conditions requiring precise dosing

• Reduces variables from mixed gas ratios

• Easier to standardize treatment protocols

Technical Notes:

• Requires advanced separation technology

• Higher cost due to complex gas separation

• May require supplemental oxygen for users with respiratory conditions

Oxyhydrogen (HHO)

Oxyhydrogen is a mixture of hydrogen and oxygen output in a 2:1 ratio (approximately 66% hydrogen and 33% oxygen) produced directly from water electrolysis without gas separation. This is sometimes referred to as “Brown’s gas” after its developer.

Pros:

• Provides oxygen delivery, which may benefit users with respiratory conditions

• Simpler technology reduces cost

• Clinical studies in COVID-19 patients showed significant improvement in dyspnea and disease severity using hydrogen-oxygen mixtures

• Natural ratio produced by water electrolysis

Safety Notes:

• Mixed hydrogen-oxygen at a 2:1 ratio is oxyhydrogen detonating gas, and requires safety protocols

• Flame arrestors and safety systems are essential

• Equipment must be designed to prevent ignition sources

The choice between pure hydrogen and oxyhydrogen depends on individual needs and health conditions.

Research suggests that both methods are effective, with oxyhydrogen potentially being more beneficial for respiratory conditions due to its enhanced oxygen delivery.

For general wellness and antioxidant benefits, pure hydrogen may be preferred due to higher molecular hydrogen concentration. For individuals with respiratory conditions or those who require supplemental oxygen, oxyhydrogen may be a more suitable option.

Clinical evidence supports both approaches, although further research is needed to determine the optimal protocols for specific health conditions. The matter of which is superior may ultimately depend on individual physiology and therapeutic goals.

When evaluating different products, consumers should consider their specific health needs and consult with healthcare providers familiar with hydrogen therapy to ensure they select the most appropriate approach.

Hydrogen gas inhalation is being explored for individuals with various health conditions, but the quality of evidence varies significantly across different applications.

Maybe Effective (Limited Evidence):

• Chronic inflammation and oxidative stress conditions

• Exercise-induced fatigue and recovery

• Cardiovascular support as adjunctive therapy

• General wellness and longevity

• Respiratory conditions such as COVID-19

• Cancer treatment support

More Research Needed:

• Neurodegenerative diseases (Parkinson’s, Alzheimer’s)

• Sleep problems and chronic fatigue

• Metabolic disorders

Hydrogen inhalation is not a cure for any condition, but it may serve as a supportive therapy that helps reduce oxidative stress and inflammation.

The absorption rate and effectiveness can vary between individuals, and responses may depend on factors such as overall health status and treatment adherence.

At recommended concentrations (2-4% by volume), molecular hydrogen is considered safe and non-toxic, with clinical trials showing minimal to no side effects. Safety looks good so far.

Important Safety Notes:

• Hydrogen is non-flammable below 4% concentration in air

• Proper equipment design with flame arrestors is required

• Well-ventilated areas prevent hydrogen accumulation

• Use only distilled water or purified water to prevent equipment contamination

Contraindications and Precautions:

• Consult healthcare providers before starting therapy

• Monitor for any unusual symptoms during initial use

• Ensure proper equipment maintenance for safety

After using hydrogen inhalation therapy for several months, I’ve noticed subtle but meaningful improvements in my overall well-being: better sleep quality, improved focus during work, reduced fatigue after intense exercise sessions, and less water retention.

Is it a miracle cure? No, and it shouldn’t be. However, as part of a comprehensive approach to health optimization, I believe hydrogen inhalation therapy is worthwhile for those seeking to reduce oxidative stress and support their body’s natural healing processes.

A lot has changed since I first learned about it, with institutions like Keio University producing high-quality clinical evidence.

More research is needed to determine optimal protocols and long-term effects, but for now, the evidence suggests that hydrogen therapy can be a beneficial addition to a healthy lifestyle.

Go ahead and check it out — prioritize safety, get quality equipment, and set realistic expectations.

Suppose you’re interested in trying hydrogen therapy for free.

In that case, I suggest registering for a free trial at The H2 Therapy if you're staying in Singapore or happen to be on a holiday trip. Read the reviews on their website at theh2therapy.com to learn more about the success stories of their clients.

Otherwise, start with reputable manufacturers and consult with healthcare providers familiar with hydrogen medicine.

The future of hydrogen therapy appears promising, and I look forward to what further research will reveal about this molecule. Towards your optimal life!